Distinct scientific studies to test the action of the drug on parturition, lactation, and development of the animal neonate weren't performed, but a general preliminary analyze in rats indicated no effect on these parameters.

It's not a complete list of achievable Uncomfortable side effects. In the event you recognize other outcomes not mentioned earlier mentioned, Get hold of your medical doctor or pharmacist.

Dispose of expired, unwanted, or unused promethazine/codeine straight away by having your medicine to a licensed DEA-registered collector or drug acquire back again plan.

Epinephrine - Due to the likely for promethazine to reverse epinephrine’s vasopressor effect, epinephrine should NOT be utilized to deal with hypotension affiliated with promethazine overdose.

The concomitant utilization of Promethazine HCl and Codeine Phosphate Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may result in reduce codeine ranges, increased norcodeine concentrations, and less metabolism via 2D6 with resultant decrease morphine degrees.

e., several copies on the gene for cytochrome P450 isoenzyme 2D6 or higher morphine concentrations). Children with slumber apnea could possibly be notably delicate to your respiratory depressant outcomes of codeine.

Affected person basic safety and wellbeing is paramount for producers of OTC medicines. Together with the MHRA, organizations which make OTC products in the united kingdom constantly check the safety of medicines through regimen pharmacovigilance measures.

Animal reproduction scientific tests haven't been executed with the drug mixture-promethazine and codeine. It's not here necessarily regarded no matter if this drug blend can result in fetal damage when administered to some Expecting lady or can impact replica capability.

Prolonged-term animal scientific studies have not been done to assess the carcinogenic opportunity of website codeine or of promethazine, nor are there other animal or human knowledge regarding carcinogenicity, mutagenicity, or impairment of fertility with these brokers.

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INDICATIONS AND Utilization Promethazine HCl and Codeine Phosphate Oral Option is a mix of codeine, here an opioid agonist; and promethazine, a phenothiazine, indicated with the short-term reduction of cough and higher respiratory symptoms involved with allergy or perhaps the prevalent cold in individuals eighteen a here long time of age and older. (1)

Your pharmacist can inform you every one of the components in the precise promethazine/codeine products and solutions they stock.

Codeine: Narcotic analgesics, including codeine, exert their Most important outcomes about the central nervous system and gastrointestinal tract. The analgesic consequences of codeine are resulting from its central action; nevertheless, the exact sites of motion haven't been decided, along with the mechanisms involved look like fairly elaborate.

If adrenal insufficiency is diagnosed, address with physiologic substitution doses of corticosteroids. Wean the affected individual off from the opioid to permit adrenal operate to Get well and keep on corticosteroid cure until adrenal function recovers. Other opioids may be tried using as some circumstances noted use of a special opioid without recurrence of adrenal insufficiency. The data out there doesn't establish any distinct opioids as currently being a lot more likely to be affiliated with adrenal insufficiency.